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The addition of a figure would also be great to provide a "big picture" snapshot of where these various cooperative and competitive behavioral effects may be occurring. Response: We appreciate your compliments regarding the paper

Instead of simply appending a non-a-amino long straight chain amino acid to the N-terminal we chose to eliminate the N-terminal amine entirely, which increased overall hydrophobicity and removed a critical hydrogen bonding site

Moreover, ammonium contributes to metabolic acidosis in the TME by forming ammonium ions (NH 4 + ), lowering the pH, disrupting redox balance, and further suppressing NK cell function

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